Lab Overview

Basic Science

Our lab addresses fundamental and translational questions in immunology using advanced visualization and cellular manipulation. The fundamental focus is on understanding the molecular and biophysical controls that balance T cell activation versus tolerance. The translational focus is on understanding the basis of rare diseases of the immune system. We are also developing diagnostic technologies for low-cost monitoring immune health and improving the diagnosis of food allergies.

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Cellular Immunology

Understanding how mechanical forces and cytoskeletal controls influence immune responses

We are fascinated by the interactions of immune cells with one another and with the extracellular matrix around them. The ultimate aim of our laboratory is to manipulate T cell signaling pathways to control immunologically-mediated diseases.

Technologies our lab uses include:

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Rare Immune Diseases

Understanding the causes of primary immunodeficiencies

We believe that understanding the genetic, molecular, and cellular underpinnings of immune diseases offers the opportunity to develop targeted therapies. The lessons we learn from patients with priamry immunodeficiencies extends our knowledge of the infections, autoimmune diseases, and cancers that affect all people.

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Contact Us

Manish's Office

Stanford University
Department of Pediatrics
300 Pasteur Drive
Grant Building, Room H307A
Stanford, CA 94305-5208
office: 650-721-1324
fax: 650-498-6077

The Lab

The Grant Building is near where Roth Way contacts Campus Drive. You can park the in multi-story lot at that corner (Parking Structure 1).

Stanford University
Department of Pediatrics
300 Pasteur Drive
Grant Building, Room S374
Stanford, CA 94305

Mailing Packages to Lab:

Stanford University
Department of Pediatrics
Grant Building, Room S374
1291 Welch Road
Stanford, CA 94305
lab phone: 650-206-2990

(1291 Welch Road is the Stanford SoM Loading Dock)


View Grant Building -- location of the Butte Lab in a larger map