Butte Lab
Our lab aims to address fundamental and therapeutic questions in immunology by developing and using tools from soft lithography and advanced microscopy to visualize and manipulate cells. The primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our laboratory is to manipulate T cell signaling pathways to control immunologically-mediated diseases. We are also developing low-cost diagnostic technologies for screening of immune-deficiencies and for autoimmunity.
Technologies our lab uses include:
- Live-cell microscopy
- Biological atomic force microscopy
- Single-molecule manipulation
- Microfluidics & soft lithography
- Lasers and optics
We welcome PhD students from Bioengineering, Mechanical Engineering, Materials Science & Engineering, Biophysics, Immunology, Physics, or Applied Physics to come visit the lab.
Dr. Butte sees patients in the Immunodeficiency Clinic at Lucile Packard Children's Hospital.
1/2012 Our first paper is published on waveguide-diagnostics technology in Applied Physics Letters.
12/2011 Manish wins Stanford Immunology Outstanding Faculty Mentor award
8/2011 Congratulations to Dan for finishing his postdoc and starting med school at Columbia Univ.
3/2011 Andrew Wang joins lab as postdoctoral fellow
2010-2012 Manish and Brian Feldman win SPARK/C-IDEA grant to develop ultra-low cost diagnotics for Type I diabetes
10/1/10 We received a Bio-X Interdisciplinary Award in a new project collaboratin with Prof. Nicholas Melosh in Materials Engineering
10/1/10 Dan Garcia, PhD joined our lab as a postdoctoral fellow.
9/1/10 Jianwei Liu, PhD joined our lab as a postdoctoral fellow, after a postdoc in the W.E. Moerner lab.
6/7/2010 Our lab was awarded an R21 grant from the NIH/NIAID to develop microfluidic devices for immune diagnostics.
6/3/2010 Congratulations to Marc Bruce for winning a Stanford Graduate Fellowship.
5/12/2010 We received a Professor Partnership award from NVIDIA Inc. for Marc's work in 3D deconvolution.
4/21/2010 Manish received a 2010 Baxter Faculty Scholar award for our work in nanotechnology.